Factors associated with target organ damage regression on the background of perindopril/amlodipin fixed dose combination therapy in hypertensive patients depending on the presence of ischemic heart disease

G.D. Radchenko, L.O. Mushtenko, Yu.M. Sirenko


Background. This article deals with an analysis of the results of EPHES trial — Evaluation of influence of fixed dose combination (FDC) Рerindopril/Amlodipine on target organ damage in patients with arterial HypErtension with or without iSchemic heart disease. There were evaluated factors associated with target organ regression in hypertensive patients with and without ischemic heart disease (IHD). Separately we compared significance of peripheral and central blood pressure (BP) for target organ damage. Materials and methods. The analysis included data of 60 patients (aged > 30 years) with hypertension: 1st group included 30 persons without IHD, 2nd group — 30 patients with IHD. All patients on day of randomi­zation were administered FDC perindopril/amlodipine in daily baseline dose 5/5 mg with up-titration to 10/10 mg every two weeks. If target BP was not achieved (> 140/90 mmHg) after 6 weeks, the indapamide 1.5 mg was added. 66.7 and 96.7 % patients of 1st and 2nd groups, respectively, received beta-bloc­kers. All patients underwent: body mass index, office and ambulatory BP measurements, evaluation of pulse wave velocity (PWV) and central systolic BP, augmentation index adjusted to heart rate 75, biochemical analysis, electrocardiography, echocardiography with Doppler, evaluation of ankle-brachial index, intima-media thickness (IMT). The follow-up period was 12 months. Results. It was found that treatment effective in BP decreasing based on FDC led to significant target organ damage regression — improving arterial stiffness and left ventricular diastolic function, decrease in urine albumin level, left ventricular hypertrophy and left atrial size. Lowering aortic PWV was lower in patients without IHD than in patients with IHD — 2.5 ± 0.2 m/s vs 4.4 ± 0.5 m/s (p < 0.005). In spite of equal decreasing of left ventricular mass indices in both groups, improvement in diastolic function (increasing E/A and redu­cing Е/Е’) was greater in patients with IHD — 64.4 and 54.1 % vs 39.8 and 23.2 % (p < 0.05 for both, respectively). IMTmax decreased significantly only in patients with IHD. Regressions of left ventricular hypertrophy, diastolic dysfunction, renal and aortic damage were associated with FDC influence on aortic BP. This impact was equal in both groups. Decrease in ambulatory systolic BP was associated independently with lowering albuminuria and left ventricular hypertrophy. Only in patients without IHD, reduction of ambulatory systolic BP was associated with improving diastolic function and left atrial size reduction, of ambulatory diastolic BP — with decreasing E/E’. In patients with IHD, older age correlated with less dynamics of aortic PWV, office systolic BP — with E/A, diabetes mellitus — with less influence on albuminuria level. Positive dynamic of IMTmax was associated with lowering aortic and ambulatory systolic BP. Independently from BP and presence of IHD, reduction of aortic PWV was correlated with muscular PWV, albuminuria, E/E’ lowering and left ventricular hypertrophy — with improving of diastolic function, reduction of left atrial size and albuminuria. Conclusions. Thus, assessing common and different factors associated with target organ damage regression depending on IHD could help in choice of antihypertensive therapy and management of patients with arterial hypertension.


arterial hypertension; ischemic heart disease; target organs; fixed combination; factors associated with target organ damage regression


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