Effective cardio- and vasoprotection of a six-month combination therapy using indapamide with amlodipine and renin-angiotensin-aldosterone system blockers in patients with high-risk essential hypertension

L.Sh. Khafisova, U.I. Nizamov, G.A. Khamidullaeva


Assessment of comparative antihypertensive and organ protective efficacy of indapamide and amlodipine with valsartan or perindopril therapy in hypertensive patients with high cardiovascular risk was the purpose of this study. Materials and methods. There were 115 patients with hypertension of II–III grade, their average age was 56.47 ± 9.18 years, and mean duration of hypertension — 10.20 ± 7.22 years. Patients received therapy with indapamide, amlodipine with valsartan and indapamide, amlodipine and perindopril. All patients underwent echocardiography. Results. Application of combined therapy using indapamide and amlodipine with valsartan or perindopril therapy in hypertensive patients with high and very high risk of cardiovascular complication allows the achievement of target systolic and diastolic blood pressure. Combined therapy contributes to significant regression of left ventricular hypertrophy. At the same time, both regimens of therapy were characterized by good tolerability. Conclusion. Combined administration of indapamide and amlodipine with renin-angiotensin-aldosterone system inhibitors is characterized by a high antihypertensive efficiency, organ protective efficacy, and good tolerability that makes this combination the most optimal and effective one in the reduction of cardiovascular complications in majority of patients.


essential hypertension; combined antihypertensive therapy


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