Clinical effectiveness of fixed-dose combination of perindopril, indapamide and amlodipine in patients with arterial hypertension and abdominal obesity. Results of 12-week observation

S.M. Koval, T.H. Strashnenko, M.Yu. Penkova, O.V. Mysnychenko, K.O. Yushko, O.M. Lytvynova


Background. Treatment of hypertension in patients with abdominal obesity is a very difficult task. Therefore, combined antihypertensive therapy with the use of two or more components is the most appropriate. The aim of the work was to study the clinical efficacy of a fixed-dose combination of perindopril, indapamide and amlodipine in patients with hypertension and abdominal obesity. Materials and methods. The study included 32 patients with uncontrolled essential hypertension and abdominal obesity before and after 12 weeks of using perindopril/indapamide/amlodipine fixed-dose triple combination on the background of atorvastatin therapy and dietary recommendations. Results. It is shown that the use of perindopril/indapamide/amlodipine fixed-dose triple combination together with moderate doses of statins and dietary recommendations in patients with uncontrolled essential hypertension and abdominal obesity leads to the positive changes in blood lipid levels and does not cause deterioration in the metabolism of carbohydrates and purines. Conclusions. High efficacy of the approved fixed-dose triple combination of antihypertensive drugs was established in this cohort of patients.


hypertension; abdominal obesity; antihypertensive therapy; fixed-dose triple combination of antihypertensive drugs


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