Efficacy and safety of trimetazidine (Сarmetadin) in the comprehensive treatment of patients with ischemic heart disease and chronic heart failure


  • O.O. Khaniukov State Institution “Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine”, Dnipro, Ukraine
  • O.V. Pysarevska State Institution “Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine”, Dnipro, Ukraine
  • M.G. Getman State Institution “Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine”, Dnipro, Ukraine
  • T.A. Simonova State Institution “Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine”, Dnipro, Ukraine
  • T.V. Lakiza State Institution “Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine”, Dnipro, Ukraine




ischemic heart disease, chronic heart failure, treatment, Сarmetadin


The purpose of study was to assess the effectiveness and safety of trimetazidine (Сarmetadin) in the comprehensive treatment of patients with ischemic heart disease and chronic heart failure. Eighty persons with ischemic heart disease (stable angina pectoris, II–III functional class) and chronic heart failure (II–III functional class, New York Heart Association classification) were included in our investigation. We performed standard clinical investigation, evaluation of laboratory indices, electrocardiography, echocardiography, daily monitoring of electrocardiogram. Patients were divided into two groups. Forty persons of the control group received comprehensive treatment — antithrombotic therapy (aspirin — 100 mg per day), beta-blocker (bisoprolol — 5–10 mg per day, depending on the initial heart rate and blood pressure, with previous dose titration), angiotensin-converting enzyme inhibitor (ramipril — 5–10 mg per day, depending on the initial blood pressure, with previous dose titration), statin (rosuvastatin — 20 mg per day) and, if necessary, nitrates and diuretics were recommended. Forty patients of the main group additionally took Сarmetadin (35 mg twice daily, modified release tablets). Observation period was 6 months. The use of Сarmetadin in the comprehensive therapy of ischemic heart disease and chronic heart failure was associated with improvement of patients’ quality of life, significant decrease in the number and duration of angina attacks, reduction of the demand for short-acting nitrates, improvement of the functional class of chronic heart failure, increase in the left ventricular ejection fraction. Besides, comprehensive treatment with Сarmetadin was well tolerated by patients — serious adverse effects were not registered.


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