Antihypertensive and prognosis-modifying effects of eplerenone in the treatment of arterial hypertension

V. Nikolaienko

Abstract


The article deals with the prospects of using eplerenone — a selective aldosterone receptor antagonist — for the treatment of patients with various degrees of arterial hypertension. A growing volume of clinical studies indicates that the multidirectional effects of eplerenone — antihypertensive, vaso-, reno-and cardioprotective, antithrombotic ones — enable to reduce blood pressure effectively, in particular, in patients with resistant hypertension, to prevent the development and progression of organ damage, to decrease the risk of total and cardiovascular mortality, to improve the quality of life and to increase its duration in patients with arterial hypertension.

Keywords


cardiovascular diseases; arterial hypertension; hyperaldosteronism; acute myocardial infarction; chronic heart failure; cardiovascular mortality; inhibitors of mineralocorticoid receptors; selective aldosterone receptor antagonists; eplerenone; Epletor

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DOI: https://doi.org/10.22141/2224-1485.2.58.2018.131063

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