DOI: https://doi.org/10.22141/2224-1485.5.61.2018.148785

Lercanidipine in the treatment of arterial hypertension: various aspects of action in clinical practice

O.L. Rekovets

Abstract


Background. One of the new third-generation calcium antagonists is lercanidipine, which, due to its high lipophilicity and vascular selectivity, can provide a gradual antihypertensive effect that lasts more than 24 hours. Materials and methods. The study included 20 patients with mild to moderate arterial hypertension (mean systolic (SBP)/diastolic blood pressure (DBP) — 149.12 ± 1.42/91.92 ± 0.93 mmHg). The criteria for inclusion in the study were: age from 18 to 75 years, mild to moderate essential hypertension. In 20 patients with mild to moderate hypertension, we studied the effect of lercanidipine at a dose of 20 mg once daily on the indicators of office blood pressure, blood pressure in daily monitoring and on central blood pressure and elastic properties of the arteries. Results. In the group of monotherapy with lercanidipine, the reduction in office SBP/DBP amounted to 12.35/8.18 mmHg (p < 0.01 for both values), heart rate increased by 4.72 bpm. In general, the target office blood pressure < 140/90 mmHg was achieved in 76.47 % of patients against the background of monotherapy with lercanidipine; in daily monitoring, blood pressure < 130/80 mmHg was achieved in 76.47 % of cases. In the group of patients treated with lercanidipine, according to ambulatory blood pressure monitoring, there was a significant decrease in the average daily SBP/DBP values by 8.65 ± 1.91/9.06 ± 2.17 mmHg, p < 0.01 for both values, and heart rate at night also significantly increased — by 5.05 ± ± 1.86 bpm, p < 0.05. The reduction in the time index for SBP and DBP for the entire period, the day period, and the reduction in the night SBP was reliable. Conclusions. According to the office measurement, treatment on the basis of lercanidipine resulted in a significant decrease in the office SBP/DBP by 12.35/8.18 mmHg. According to daily blood pressure monitoring, therapy with lercanidipine 20 mg significantly reduced daily SBP/DBP — by 8.65/9.06 mmHg, as well as central blood pressure — by 12.18 mmHg. The proportion of patients who achieved the target levels of office blood pressure and blood pressure in daily monitoring was the same — 76.47 %. There was no significant effect of lercanidipine on changes in heart rate variability. Lercanidipine administration was well tolerated by patients.


Keywords


arterial hypertension; lercanidipine; treatment

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