DOI: https://doi.org/10.22141/2224-1485.5.61.2018.148787

The relevance of using organic nitrates in the modern therapy of stable coronary artery disease

H.F. Lysenko, O.I. Moiseienko

Abstract


The article deals with the use of nitrates in modern therapy of coronary artery disease, angina pectoris. The mechanisms of action of nitrates and the main indications for the use of various dosage forms are considered. Short-acting nitrates (nitroglycerin and isosorbide dinitrate) remain mandatory standard component of therapy for angina pectoris. These drugs, due to the significant antianginal effect, can be used to relieve various forms of angina pectoris/effort angina, unstable (acute coronary syndrome), post-infarction, vasospastic. Long-acting nitrates are recommended as second-line drugs to prevent angina attacks. The article also discusses issues of tolerance to nitrates, the possibilities of its overcoming and the features of using these drugs in different groups of patients, describes the individual characteristics of nitrate use.

Keywords


short-acting nitrates; isosorbide dinitrate; antianginal therapy

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