Results of an international symposium on arterial hypertension and calcium channel blockers: focus on lercanidipine

O.L. Rekovets


The review presents the results of a symposium with the participation of main experts in the field of hypertension from all over the world on the topic “Current perspective on the use of calcium channel blockers in the treatment of hypertensive patients”. It was noted that all 5 currently widely used classes of antihypertensive drugs, including calcium channel blockers (CCBs), are able to lower blood pressure and constitute the basis of antihypertensive therapy. But the ability to reduce the risk of other cardiovascular events may vary between classes. For example, CCBs have been shown to reduce the risk of stroke, major cardiovascular events, cardiovascular and all-cause mortality. The discussion also touched upon the fact that CCBs are included in the category of “best drugs” in the management of target organ damage. So, for left ventricular hypertrophy, angiotensin-converting enzyme inhibitors and CCBs were named the best, for reducing small arteries remodeling — angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and CCBs. New CCBs are expected to be among the best treatments for chronic kidney disease. When considering individual CCB representatives, the main focus was on lercanidipine, a relatively new third generation lipophilic dihydropyridine with high vascular selectivity. In addition to all the properties listed above, it is characterized by a number of additional remarkable features: the slow onset of action, leading to a gradual decrease in blood pressure and the prevention of reflex tachycardia; fewer side effects, especially ankle and pedal edema. For example, the edema frequency in the group with lercanidipine was 9.3 %, in the group with amlodipine 19 %. Unlike many other CCBs, lercanidipine dilates both afferent and efferent arterioles that potentially reduces glomerular hypertension and may contribute to nephroprotection. For example, the combination of lercanidipine + enalapril steadily reduced albuminuria, while amlodipine + enalapril did not. In general, the efficacy of lercanidipine has been confirmed in patients with varying degrees of hypertension; in patients of all ages (young, middle-aged and elderly); with isolated systolic hypertension; in patients with diabetes and renal impairment. The drug was well tolerated.


calcium channel blockers; lercanidipine; arterial hypertension; review


Williams B., Mancia G., Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J. Hypertens. 2018. V. 36, № 10. P. 1953-2041.

Mancia G., Tsioufis K. Current perspective on the use of calcium channel blockers to treat hypertensive patients: the role of lercanidipine. Future Cardiol. 2019 [Epub ahead of print].

Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension. Effects of various classes of antihypertensive drugs-overview and meta-analyses. J. Hypertens. 2015. V. 33, № 2. P. 195-211.

Grassi G., Robles N.R., Seravalle G., Fici F. Lercanidipine in the Management of Hypertension: An Update. J. Pharmacol. Pharmacother. 2017. V. 8, № 4. P. 155-165.

Pruijm M.T., Maillard M.P., Burnier M. Patient adherence and the choice of antihypertensive drugs: focus on lercanidipine. Vasc. Health Risk Manag. 2008. V. 4, № 6. P. 1159-1166.

Herbette L.G., Vecchiarelli M., Sartani A., Leonardi A. Lercanidipine: short plasma half-life, long duration of action and high cholesterol tolerance. Updated molecular model to rationa-lize its pharmacokinetic properties. Blood Press Suppl. 1998. V. 2. P. 10-17.

Borghi C. Lercanidipine in hypertension. Vasc. Health Risk Manag. 2005. V. 1, № 3. P. 173-182.

Treatment of proteinuria with lercanidipine associated with renin-angiotensin axis-blocking drugs / Robles N.R., Romero B., de Vinuesa E.G. et al. Ren. Fail. 2010. V. 32, № 2. P. 192-197.

Effect of calcium antagonists on glomerular arterioles in spontaneously hypertensive rats / Sabbatini M., Leonardi A., Testa R. et al. Hypertension. 2000. V. 35, № 3. P. 775-779.

Hayashi K., Wakino S., Sugano N. et al. Ca2+ channel subtypes and pharmacology in the kidney. Circ. Res. 2007. V. 100, № 3. P. 342-353.

Cerbai E., Mugelli A. Lercanidipine and T-type calcium current. Eur. Rev. Med. Pharmacol. Sci. 2018. V. 22, № 12. P. 4025-4031.

Barrios V., Navarro A., Esteras A. et al. Antihypertensive efficacy and tolerability of lercanidipine in daily clinical practice. The ELYPSE Study. Eficacia de Lercanidipino y su Perfil de Seguridad. Blood Press. 2002. V. 11, № 2. P. 95-100.

Cicero A.F., Gerocarni B., Rosticci M., Borghi C. Blood pressure and metabolic effect of a combination of lercanidipine with different antihypertensive drugs in clinical practice. Clin. Exp. Hypertens. 2012. V. 34, № 2. P. 113-117.

Leonetti G., Magnani B., Pessina A.C. et al. Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives. Am. J. Hypertens. 2002. V. 15, № 11. P. 932-940.

Bakris G.L., Sarafidis P.A., Weir M.R. et al. Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events

(ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial. Lancet. 2010. V. 375, № 9721. P. 1173-1181.

Dalla Vestra M., Pozza G., Mosca A. et al. Effect of lercanidipine compared with ramipril on albumin excretion rate in hypertensive Type 2 diabetic patients with microalbuminuria: DIAL study (diabete, ipertensione, albuminuria, lercanidipina). Diabetes Nutr. Metab. 2004. V. 17, № 5. P. 259-266.

Robles N.R., Ocon J., Gomez C.F. et al. Lercanidipine in patients with chronic renal failure: the ZAFRA study. Ren. Fail. 2005. V. 27, № 1. P. 73-80.

Robles N.R., Calvo C., Sobrino J. et al. Lercanidipine valuable effect on urine protein losses: the RED LEVEL study. Curr. Med. Res. Opin. 2016. V. 32 (Suppl. 2). P. 29-34.

Copyright (c) 2019 HYPERTENSION

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта