The Pathogenetic Role of Apelin in the Development of Hypertension

S.M. Koval, K.O. Yushko, T.H. Starchenko, I.A. Korniichuk, O.V. Lytvynova


The article presents the analysis of the results of international, national and own studies on the pathogenetic role of peptide apelin in the development of hypertension and its complications. Apelin interactions with the blood pressure regulation mechanisms, the renin-angiotensin system components, the target organ damage processes were shown. The possibility of applying the apelin and its synthetic analogues as a potentially new class of drugs for the treatment of hypertension and its complications has been discussed.


apelin; hypertension; renin-angiotensin system; cardiac remodeling; therapeutic options


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