DOI: https://doi.org/10.22141/2224-1485.4.48.2016.76991

Endothelium and Systemic Inflammation: Role of Nuclear Transcription Factors and Therapeutic Possibilities (Literature Review)

N.I. Degtjar, N.D. Gerasimenko, M.S. Rasin

Abstract


Endothelium plays a crucial role in human physiology and pathology. Endothelial dysfunction: formation of proinflammatory and prothrombotic phenotype of endothelial cells (EC), excessive production of inflammatory cytokines, reduced production of vasodilators and increased — of vasoconstrictors and prothrombotic mediators is the basis of the pathogenesis of systemic inflammation (SI) and diseases associated with it: hypertension, atherosclerosis, coronary heart disease, obesity, diabetes mellitus 2 type. Nuclear transcription factor kappa B (NFkB) is the main inducer of SI in the endothelial cells, and peroxisome proliferator-activated receptors (PPAR-α, -β/-δ and -γ), NFkB antagonists, are the regulators of SI severity. Studying the molecular mechanisms of NFkB and PPAR action enables the use of NFkB antagonist — metformine, and PPAR-γ agonist — pioglitazone in the treatment of diseases associated with SI, as well as hope for the creation of new drugs.


Keywords


endothelium; endothelial dysfunction; systemic inflammation; nuclear transcription factor kappa B; peroxisome proliferator-activated receptors; metformin; pioglitazone

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