Antihypertensive Effectiveness of Hiten (Perindopril) in Patients with Mild to Moderate Arterial Hypertension
Aim. To study antihypertensive efficacy and tolerability of the drug Hiten (perindopril) manufactured by «Aurobindo Pharma Limited», India, in patients with mild to moderate arterial hypertension. Methods. The study included 53 patients. The control of office blood pressure (BP) and heart rate, effectiveness of the therapy was made, we have recorded the cases of adverse reactions, performed ambulatory BP monitoring, the control of biochemical parameters of the blood serum, total blood count. Hiten at a dose of 4–8 mg 1 time a day was administered for 30 days. In cases when the target level of BP was not reached, if necessary, hydrochlorothiazide 12.5 mg 1 time per day was added. The total course of treatment for one patient was 6 months. The average age of the patients was 51.38 ± 1.40 years, body mass index — 29.50 ± 0.59 kg/m2.
Baseline level of average office systolic BP (SBP) and diasto-lic BP (DBP) in the whole group was 156.77 ± 0.66 mmHg and 95.19 ± 0.98 mmHg. Results. It was found that in patients with mild to moderate hypertension, the treatment by Hiten (perindopril) in a dose of 4–8 mg (alone or in combination with hydrochlorothiazide) provides a significant decrease in both office SBP — by 28.67 mmHg, DBP — by 14.57 mmHg, and average daily SBP — by 14.14 mmHg and DBP — by 7.55 mmHg, as well as lowers the indices of time and pressure. Target BP according to office measurements (< 140/90 mmHg) was achieved in 88 % of patients, according to ambulatory BP monitoring (< 130/80 mmHg) — in 78 % of cases. Withdrawal of the drug was in 3 patients (5.6 %). Conclusion. Results of the study indicate a high antihypertensive efficacy and good tolerability of therapy with Hiten (perindopril) — both as monotherapy and in combination with hydrochlorothiazide in patients with mild to moderate hypertension.
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