Efficacy and Safety of Fixed Combinations of Slow Calcium Channels Blockers, Angiotensin Receptor Blockers and Thiazide Diuretics in the Treatment of Hypertension

I.G. Kupnovytska, I.P. Kutynska, V.I. Klymenko, O.I. Danyliuk

Abstract


This paper presents an analysis of the results of researches on the effectiveness and safety of fixed combinations of slow calcium channel blocker (CCB) amlodipine and angiotensin receptor blocker (ARB) valsartan (Combisart) and amlodipine, valsartan and thiazide diuretic hydrochlorothiazide (Combisart H) of PJSC «Kyiv Vitamin Factory» in comparison with the drugs Exforge and Exforge H (Novartis Pharma, Switzerland) in the treatment of patients with hypertension stage II–III. We have established the therapeutic equivalence of Combisart and Combisart H to the referent ones — Exforge and Exforge N. The effectiveness of the studied drugs was shown in terms of lowering blood pressure, improving its control over the day with a combination of ARB and CCB with thiazide diuretic, a good tolerability of Combisart and Combisart H that increases adherence of patients to the treatment of hypertension.


Keywords


arterial hypertension; treatment; efficacy; safety

References


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DOI: https://doi.org/10.22141/2224-1485.4.48.2016.77000

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