Acetylsalicylic Acid as an Effective and Safe Basis for Antiplatelet Therapy

A.E. Lievykh, V.I. Mamchur

Abstract


Data about pharmacodynamics, pharmacokinetics, clinical efficacy and safety of long-term therapy with acetylsalicylic acid (ASA) in patients with cardiovascular diseases are presented in the review paper. The main practical ways to reduce the possible gastrointestinal complications are discussed. Convincing positive results of clinical trials and so-called gastric toxicity of ASA together with the need of prolonged use of the preparation as an antiaggregant were the basis for the appearance of the various do­sage forms of ASA: soluble, with controlled release, enteric-coated, local, buffer, as well as combined agents containing ASA and substances with antacid effect. To date, the most convincing evidence for the efficacy and gastrointestinal safety has been obtained for enteric forms of ASA.


Keywords


acetylsalicylic acid; efficacy; safety

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DOI: https://doi.org/10.22141/2224-1485.6.44.2015.80882

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