Evaluation of Antihypertensive and Cardioprotective Efficacy of Indapamide as Monotherapy in Patients with Mild to Moderate Hypertension

L.Sh. Khafizova, G.A. Khamidullayeva, N.Z. Srozhidinova, G.Zh. Abdullayeva, N.Sh. Shakirova, N.B. Tursunova

Abstract


The aim of research: to study of clinical and cardioprotective efficacy of 12-week indapamide monotherapy in patients with mild to moderate hypertension.
Materials and Methods of Study. The study included 33 patients with essential hypertension stage I–II and hypertension of 1–2 degree (mild to moderate) (ESH/ESC 2007), males and females, mean age was 47.61 ± 9.62 years, mean duration of disease — 6.21 ± 4.31 years. As antihypertensive therapy we administered indapamide 2.5 mg/day. Echocardiography was performed in accordance with American Society of Echocardiography Guidelines in the M- and B-mode on the device of ultrasound EnVisor C (Philips, Holland).
The Results of Study. During the 12-week monotherapy with indapamide there was marked a high antihypertensive efficacy of this agent in patients with mild to moderate hypertension with the achievement of the target level of systolic and diastolic blood pressure in 75.6 % of patients. High antihypertensive efficacy of the drug was also characterized by reliable cardioprotection, regression of left ventricular hypertrophy in 52 % of patients, reduction of left ventricular mass index by 10.86 %.
Conclusion. Indapamide as monotherapy is recommended as antihypertensive drug, which has cardioprotective efficacy, for treatment patients with mild to moderate hypertension.


Keywords


essential hypertension; left ventricular hypertrophy; antihypertensive therapy; indapamide

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DOI: https://doi.org/10.22141/2224-1485.2.34.2014.82707

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