Clinical Significance of Blood Pressure Measured in Different Ways in Patients with Hypertension

H.D. Radchenko, O.O. Torbas, Yu.M. Sіrenko


Objective. To evaluate the presence and degree of correlation of central, office and daily blood pressure (BP) with the indicators of target organ damage. Materials and Methods. The study involved 62 patients with essential hypertension of various degrees, aged 49.6 ± 2.1 years. Results. Central systolic BP (SBP) and pulse pressure (PP) (unlike the office and daily average ones) significantly correlated with all indicators, except those which characterize the renal lesion and ancle-brachial index. The strongest relationship was with pulse wave velocity in elastic (PWVe) (r = 0.57, p < 0.001) and muscular arteries (PWVm) (r = 0.45, P < 0.001). PWVe independently correlated only with office diastolic BP (β = 4.3, P = 0.042), central SBP (β = 6.6, P = 0.05) and PP (β = 4.5, P = 0.03) and PWVm — only with central PP (β = 0.50, P < 0.001). Central PP (β = 0.40, P = 0.011; and β = 0.34, P = 0.025) was associated with intima-media thickness. Diastolic dysfunction (Е/Е′) was significantly associated only with central SBP (β = 0.55, P = 0.039).
Conclusion. BP level in the aorta has an influence on the formation of target organ damage, particularly on vessels that manifested by violations of their elastic properties, or thickening of the intima-media.


hypertension; central blood pressure; target organs


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