Hyperuricemia and Arterial Hypertension — is There a Correlation?

L.A. Mishchenko

Abstract


Based on the analysis of references, the article deals with the current state of studying the role of hyperuricemia in the development and progression of arterial hypertension. We describe the evolution of scientific understanding of the uric acid — from the etiological factor of gout to so-called new risk factor for cardiovascular complications. The article presents the results of studies demonstrating the value of hyperuricemia in the formation of subclinical hypertensive heart and kidney disease, as well as the effect of different antihypertensive drugs on serum uric acid levels. The expediency of further studying the role of hyperuricemia in the progression of arterial hypertension and possibilities of its medical correction are substantiated.

Keywords


hyperuricemia; uric acid; arterial hypertension; left ventricular hypertrophy; glomerular filtration rate

References


Міщенко Л.А. Зв’язок гіперурикемії з ураженням органів-мішеней у хворих на гіпертонічну хворобу / Л.А. Міщенко // Кардиология: от науки к практике. — 2015. — № 2(15). — С. 41-51.

Міщенко Л.А. Особливості зв’язку нових факторів серцево-судинного ризику з гіпертрофією лівого шлуночка у чоловіків і жінок, хворих на гіпертонічну хворобу / Л.А. Міщенко // Запорожский медицинский журнал. — 2012. — Т. 73, № 4. — С. 31-34.

Міщенко Л.А. Предиктори погіршання функціонального стану нирок у хворих на гіпертонічну хворобу з гіпертензивною нефропатією / Л.А. Міщенко, Є.П. Свіщенко, В.Б. Безродний // Український кардіологічний журнал. — 2012. — № 1. — С. 8-12.

Feig D.I. Hyperuricemia and hypertension / D.I. Feig // Advances in Chronic Kidney Disease. — 2012. — Vol. 19. — P. 377-385.

Feig D.I. Uric acid and cardiovascular risk / D.I. Feig, D.H. Rang, R.J. Johnson // N. Engl. J. Med. — 2008. — Vol. 359. — P. 1811-1821.

Stack A.G. Independent and conjoint associations of gout and hyperuricaemia with total and cardiovascular mortali­ty / A.G. Stack, A. Hanley, L.F. Casserly [et al.] // QJM. — 2013. — Vol. 106. — P. 647-658.

Krishnan E. Gout and the risk of acute myocardial infarction / E. Krishnan, J.F. Baker, D.E. Furst [et al.] // Arthritis Rheum. — 2006. — Vol. 54. — P. 2688-2696.

Hoieggen A. The impact of serum uric acid on cardiovascular outcomes in the LIFE study / A. Hoieggen, M.H. Alderman, S.E. Kjeldsen [et al.] // Kidney Int. — 2004. — Vol. 65. — P. 1041-1049.

Verdecchia P. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension: the PIUMA study / P. Verdecchia, G. Schillaci, G.P. Reboldi [et al.] // Hypertens. — 2000. — Vol. 36. — P. 1072-1078.

Hozawa A. Serum uric acid and risk of ischemic stroke: the ARIC study / A. Hozawa, A.R. Folsom, H. Ibrahim [et al.] // Atherosclerosis. — 2006. — Vol.187. — P. 401-407.

Vannorsdalla D.T. Higher Baseline Serum Uric Acid is Associated with Poorer Cognition but Not Rates of Cognitive Decline in Women / D.T. Vannorsdalla, A.M. Kueiderc, M.C. Carlsonc // Exp. Gerontol. — 2014. — Vol. 60. — P. 136-139.

Beydoun M.A. Serum Uric Acid and Its Association with Longitudinal Cognitive Change Among Urban Adults / M.A. Beydoun, J.A. Canas, G.A. Dore [et al.] // J. Alzheimers. Dis. — 2016. — Vol. 52. — P. 1415-1430.

Krishnan E. Hyperuricemia and Incidence of Hypertension Among Men Without Metabolic Syndrome / E. Krishnan, C.K. Kwoh, H.R. Schumacher [et al.] // Hypertension. — 2007. — Vol. 49. — P. 298-303.

Forman J. Uric acid and insulin sensitivity and risk of incident of hypertension / J. Forman, H. Choi, G. Curhan // Arch. Intern. Med. — 2009. — Vol. 169. — P. 155-162.

Zhang W. Plasma uric acid and hypertension in a Chinese community: prospective study and meta-analysis / W. Zhang, K. Sun, Y. Yang [et al.] // Clin. Chem. — 2009. — Vol. 55. — P. 2026-2034.

Bombelli M. Prognostic value of serum uric acid: new-onset in and out-of-office hypertension and long-term mortality / M. Bombelli, I. Ronchi, M. Volpe // J. Hypertens. — 2014. — Vol. 32. — P. 1237-1244.

Grayson P.C. Hyperuricemia and incident of hypertension: a systematic review and meta-analysis / P.C. Grayson, S.Y. Kim, M. LaValley [et al.] // Arthritis Care Res. — 2011. — Vol. 63. — P. 102-110.

Feig D.I. Hyperuricemia in childhood primary hypertension / D.I. Feig, R.J. Johnson // Hypertens. — 2003. — Vol. 42. — P. 247-252.

Feig D.I. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomi­zed trial / D.I. Feig, B. Soletski, R.J. Johnson // JAMA. — 2008. — Vol. 300. — P. 924-932.

Beattie C.J. Allopurinol initiation and change in blood pressure in older adults with hypertension / C.J. Beattie, R.L. Fulton, P. Higgins [et al.] // Hypertension. — 2014. — Vol. 65. — P. 1102-1107.

Agarwal V. Effect of Allopurinol on Blood Pressure: A Systematic Review and Meta-Analysis / V. Agarwal, N. Hans, F.H. Messerli [et al.] // J. Clin. Hypertens. — 2013. — Vol. 15. — P. 435-442.

Mazzali M. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism / M. Mazzali, J. Hughes, Y.G. Kim [et al.] // Hypertension. — 2001. — Vol. 38. — P. 1101-1106.

Mazzali M. Hyperuricemia induсes a primary arteriolopathy in rats by a blood pressure independent mechanism / M. Mazzali, J. Kanellis, E. Han [et al.] // Am. J. Physiol. Renal. Physiol. — 2002. — Vol. 282. — P. 991-997.

Sanchez-Lozada L.G. Mild hyperuricemia induces vasoconstriction and maintains glomerullar hypertension in normal and remnant kidney rats / L.G. Sanchez-Lozada, E. Tapia, J. Santamari [et al.] // Kidney Intern. — 2005. — Vol. 67. — P. 237-247.

Corry D.B. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system / D.B. Corry, P. Eslami, K. Yamamoto [et al.] // J. Hypertens. — 2008. — Vol. 26. — P. 269-275.

Sanchez-Lozada L.G. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction / M.A. Yu, L.G. Sanchez-Lozada, R.J. Johnson [et al.] // J. Hypertens. — 2010. — Vol. 28. — P. 1234-1242.

Sanchez-Lozada L.G. Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentration / L.G. Sanchez-Lozada, M.A. Lanaspa, M. Cristobal-Garcia [et al.] // Nephron. Exp. Nephrol. — 2012. — Vol. 121. — P. e71-e78.

Iwashima Y. Uric acid, left ventricular mass index, and risk of cardiovascular disease in essential hypertension / Y. Iwashima, T. Horio, K. Kamide // Hypertens. — 2006. — Vol. 47. — P. 195-202.

Tsioufis C. The diverse association of uric acid with low grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives / C. Tsioufis, S. Kyvelou, K. Dimit­riadis [et al.] // J. Hum. Hypertens. — 2011. — Vol. 25. — P. 554-559.

Iseki K. Significance of hyperuricemia on the early detection of renal failure in cohort of screened subjects / K. Iseki, S. Oshiro, M. Tozawa [et al.] // Hypertens. Res. — 2001. — Vol. 24. — P. 691-697.

Obermayr R.P. Elevated uric acid increases the risk for kidney disease / R.P. Obermayr, C. Temml, G. Gutjahr [et al.] // J. Am. Soc. Nephrol. — 2008. — Vol. 19. — P. 2407-2413.

Borges R.L. Uric acid as a marker for renal dysfunction in hypertensive women on diuretic and non-diuretic therapy / R.L. Borges, A.H. Hirota, B.M. Quinto [et al.] // J. Clin. Hypertens. — 2009. — Vol. 5. — P. 253-259

Madero M. Uric acid and long-term outcomes in CKD / M. Madero, M.J. Sarnak, X. Wang // Am. J. Kidney Dis. — 2009. — Vol. 53. — P. 796-803.

Kanbay M. Serum uric acid independently predicts cardiovascular events in advanced nephropathy / M. Kanbay, M.I. Yilmaz, A. Sonmez [et al.] // Am. J. Nephrol. — 2012. — Vol. 36. — P. 324-331.

Choncol M. Relationship of uric acid with progression of kidney disease / M. Choncol, M.G. Schlipak, R. Katz [et al.] // Am. J. Kidney Dis. — 2007. — Vol. 50. — P. 239-247.

Sturm G. Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The Mild to Moderate Kidney Disease (MMKD) Study / G. Sturm, B. Kollerits, U. Neyer [et al.] // Exp. Gerontol. — 2008. — Vol. 43. — P. 347-352.

Krishnan E. Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction / E. Krishnan, B.J. Pandya, B. Lingala [et al.] // Arthritis Research & Therapy. — 2012. — Vol. 14. — P. 2-10.

Khanna D. 2012 American College of Rheumatology Guidelines for Management of Gout Part II: Therapy and Anti-inflammatory Prophylaxis of Acute Gouty Arthritis / D. Khanna, P.P. Khanna, J.D. Fitzgerald [et al.] // Arthritis Care Res. (Hoboken). — 2012. — Vol. 64. — P. 1447-1461.

Borghi C. Serum uric acid and the risk of cardiovascular and renal disease / Borghi С., Rosei E.A., Bardin T. [et al.] // J. Hypertens. — 2015. — Vol. 33. — P. 1729-1741.

Matsumura K. Effect of losartan on serum uric acid in hypertension treated with a diuretic: the COMFORT study / K. Matsumura, H. Arima, M. Tominaga [et al.] // Clin. Exp. Hypertens. — 2015. — Vol. 37(3). — P. 192-196.

Smink P.A. An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post hoc analysis of the RENAAL and IDNT trials / P.A. Smink, S.J. Bakker, G.D. Laverman [et al.] // J. Hypertens. — 2012. — Vol. 30. — P. 1022-1028.

Miao Y. Effect of a reduction in uric acid on renal outcomes during losartan treatment: a post hoc analysis of the reduction of endpoints in non-insulin-dependent diabetes mellitus with the Angiotensin II Antagonist Losartan Trial / Y. Miao, S.A. Ottenbros, G.D. Laverman [et al.] // Hypertens. — 2011. — Vol. 58. — P. 2-7.

Mishchenko L. Effect of rosuvastatin on renal function and metabolic parameters at essential hypertensive patients / L. Mishchenko, O. Matova, T. Ovdiienko [et al.] // J. Am. Soc. Hypertens. — 2016. — Vol. 10(4S). — P. e10-e13.

Borghi C. Lack of control of hypertension in primary cardiovascular disease prevention in Europe: Results from the EURIKA study / C. Borghi, F. Tubach, G. De Backer [et al.] // Int. J. Cardiol. — 2016. — Vol. 218. — P. 83-88.




DOI: https://doi.org/10.22141/2224-1485.5.49.2016.83865

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