Possibilities of Valsaсor In the Cognitive Decline Correction in Essential Hypertension

O.O. Yakovleva, O.V. Kyrychenko

Abstract


Essential hypertension plays an important role in the development and progression of cognitive impairment to dementia stage. The aim of the study is the optimization of the therapy of patients with essential hypertension by assessing the dynamics of cognitive function against therapy with Valsacor compared to amlodipine. The study included 67 patients with essential hypertension of I–III stage, aged 56.30 ± 1.74 years. After randomization, patients of I clinical group (n = 33) were administered amlodipine, and patients of II one (n = 34) — Valsacor and diuretic agent as needed. Follow-up was 3 months. The control group consisted of 34 apparently healthy individuals. The pharmacotherapy efficacy was assessed by results of office and daily measurement of blood pressure. For the neuropsychological tests, Schulte table were used. Patients with essential hypertension need more time to perform tasks than apparently healthy individuals (p < 0.05). Comparison of the results of initial and control testing of patients of the I group didn’t reveal differences (p > 0.05). At the control testing patients of II group spent 18.94 % less total time in comparison with the primary results (p < 0.05). In patients with essential hypertension the rate of reaction has slowed compared to apparently healthy persons (p < 0.05). Antihypertensive therapy with amlodipine did not affect the reaction rate. Pharmacotherapy with Valsacor improves the results of neuropsychological testing compared to baseline data (p < 0.05).


Keywords


essential hypertension; Valsacor; amlodipine; cognitive functions; Schulte tables

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DOI: https://doi.org/10.22141/2224-1485.6.32.2013.86410

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