Possibilities of Valsaсor In the Cognitive Decline Correction in Essential Hypertension

O.O. Yakovleva, O.V. Kyrychenko


Essential hypertension plays an important role in the development and progression of cognitive impairment to dementia stage. The aim of the study is the optimization of the therapy of patients with essential hypertension by assessing the dynamics of cognitive function against therapy with Valsacor compared to amlodipine. The study included 67 patients with essential hypertension of I–III stage, aged 56.30 ± 1.74 years. After randomization, patients of I clinical group (n = 33) were administered amlodipine, and patients of II one (n = 34) — Valsacor and diuretic agent as needed. Follow-up was 3 months. The control group consisted of 34 apparently healthy individuals. The pharmacotherapy efficacy was assessed by results of office and daily measurement of blood pressure. For the neuropsychological tests, Schulte table were used. Patients with essential hypertension need more time to perform tasks than apparently healthy individuals (p < 0.05). Comparison of the results of initial and control testing of patients of the I group didn’t reveal differences (p > 0.05). At the control testing patients of II group spent 18.94 % less total time in comparison with the primary results (p < 0.05). In patients with essential hypertension the rate of reaction has slowed compared to apparently healthy persons (p < 0.05). Antihypertensive therapy with amlodipine did not affect the reaction rate. Pharmacotherapy with Valsacor improves the results of neuropsychological testing compared to baseline data (p < 0.05).


essential hypertension; Valsacor; amlodipine; cognitive functions; Schulte tables


Аббасова Л.И. Клиническая значимость профилактики, диагностики и лечения когнитивных нарушений у больных артериальной гипертензией / Л.И. Аббасова // Вісник проблем біології і медицини. — 2011. — Т. 1, Вип. 2. — С. 96-97.

Альманах психологических тестов. — М.: КСП, 1996. — 397[1] с.

Грибачева И.А. Сосудистые когнитивные расстройства и современные подходы к их коррекции / И.А. Грибачова // Сибирский медицинский журнал. — 2009. — № 3. — С. 58-62.

Левин О.С. Дисциркуляторная энцефалопатия: от патогенеза к лечению / О.С. Левин // Трудный пациент. — 2010. — Т. 8, № 4. — С. 8-15.

Dowlatshahi D., Hill M.D. Angiotensin receptor blockers and secondary stroke prevention: the MOSES study // Expert. Rev. Cardiovasc. Ther. — 2009 May. — 7(5). — 459-64. doi: 10.1586/erc.09.3.

Fournier A., Messerli F.H, Achard J.M., Fernandez L. Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent randomized clinical trials // J. Am. Coll. Cardiol. — 2004 Apr. — 21; 43(8). — 1343-7.

Hajjar I., Hart M., Chen Y.L., Mack W., Milberg W., Chui H., Lipsitz L. Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial // Arch. Intern. Med. — 2012 Mar. — 12; 172(5). — 442-4. doi: 10.1001/archinternmed.2011.1391.

Hanon O., Berrou J.P., Negre-Pages L., Goch J.H., Nádházi Z., Petrella R., Sedefdjian A., Sévenier F., Shlyakhto E.V., Pathak A. Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: primary results of the Observational Study on Cognitive Function and Systolic Blood Pressure Reduction open-label study // J. Hypertens. — 2008 Aug. — 26(8). — 1642-50. doi: 10.1097/HJH.0b013e328301a280.

Mancia G., Laurent S., Agabiti-Rosei E., Ambrosioni E., Burnier M., Caulfield M.J., Cifkova R., Clément D., Coca A., Dominiczak A., Erdine S., Fagard R. [et al.]; European Society of Hypertension. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document // J. Hypertens. — 2009 Nov. — 27(11). — 2121-58. doi: 10.1097/HJH.0b013e328333146d.

McGuinness B., Todd S., Passmore P., Bullock R. Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia // Cochrane Database of Systematic Reviews. — 2009. — Issue 4. Art. No.: CD004034. DOI: 10.1002/14651858.CD004034.

Radaideh G.A., Choueiry P., Ismail A., Eid E., Berrou J.P., Sedefdjian A., Sévenier F., Pathak A. Eprosartan-based hypertension therapy, systolic arterial blood pressure and cognitive function: analysis of Middle East data from the OSCAR study // Vasc. Health Risk Manag. — 2011. — 7. — 491-5. doi: 10.2147/VHRM.S19699. Epub 2011 Aug 1.

Copyright (c) 2016 HYPERTENSION

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта