Do We Always Prescribe Life-Saving Medicines to Our Patients, or Indications for Statin Therapy and Statin Administration in Actual Practice (Based on the СИСТЕМА Study)


  • V.I. Tseluiko статини; артеріальна гіпертензія; офіс­ний АТ; гіполіпідемічна терапія



statins, arterial hypertension, office blood pressure, lipid-lowering therapy


The article presents the results of the СИСТЕМА study, which analyzed the prescriptions of statins to the patients with hypertension, who sought help from a cardiologist in the out-patient hospital. It was found that in actual clinical practice, there is an underestimation of the risk for the patient by doctors and the possibility to improve prognosis ­using statins. Most often, but less frequently than they should, cardiologists prescribe statins to the patients with myocardial infarction. In the presents of a history of stroke, diabetes mellitus, chronic kidney disease or high blood pressure, statins are being prescribed by a cardiologist in less than half of the patients.


CCT Collaboration // Lancet. — 2015. — 385. — 1397-405.

Taylor F., Ward K., Moore T.H. et al. // Cochrane Database Syst. Rev. — 2011. — 1. — CD004816.

Colhoun H.M., Betteridge D.J., Durrington P.N. et al. Оn behalf of the CARDS investigators. Primary prevention of cardiovascular desease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicenter randomized placebo-controlled trial // Lancet. — 2004. — 364. — 685-96.

Athyros V.G., Mikhailidis D.P., Papageorgiou A.A. et al. The effect of statins versus untreated dyslipidaemia on renal function in patients with coronary heart disease. A subgroup analysis of the Greek atorvastatin and coronary heart disease evaluation (GREACE) study // J. Clin. Pathol. — 2004. — 57(7). — 728-734.

Коваленко В.М. Проблеми здоров’я і медичної допомоги та модель покращення в сучасних умовах: Посібник. — К., 2016.

Лапач С.Н., Чубенко А.В., Бабич П.Н. Статистические методы в медико-биологических исследованиях с использованием Exel. — К.: Морион, 2001.

Stone N.J. et al. 2013 ACC/AHA Blood Cholesterol Guideline.

Catapano et al. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias // European Heart Journal. — 2016.

Стабільна ішемічна хвороба серця: Адаптована клінічна настанова, заснована на доказах. — 2016.

Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) // Lancet. — 1994. — 344. — 1383-1389.

American Diabetes Association. Standards of Medical Care in Diabetes — 2016 // The Journal оf Clinical аnd Applied Research аnd Education. — 2016.

Am. J. Kidney Dis. — 2002. — 39(2 suppl. 1). — 818.



Clinical Researches