Activators of Angiogenesis and Cardiovascular Diseases. Results of Study of Blood Levels of Vascular Endothelial Growth Factor and Angiopoetin-2 in Patients with Essential Hypertension

S.M. Koval, O.V. Mysnichenko, I.O. Snegurskaya, O.V. Vysotskaya, O.I. Tsigankov, I.A. Korneychuk, M.Yu. Penkova


Blood levels of vascular endothelial growth factor and angiopoetin-2, powerful activators of angiogenesis with proinflammatory activity were studied in hypertensive patients. Significantly higher vascular endothelial growth factor and angiopoetin-2 blood levels have been determined in hypertensive patients compared to normotensive control subjects. The blood levels of angiopoetin-2 were found to be enhanced in hypertensive patients while deterioration of essential hypertensive and at presence of such metabolic disorders as abdominal obesity, fasting hyperglycemia, glucose intolerance, hyperuricemia and combined dyslipidemia. Vascular endothelial growth factor blood levels were higher in hypertensive patients with stable angina pectoris compared to the patients without angina pectoris. The data obtained indicate an important role of angiogenesis activation in the development of essential hypertension and its cardiovascular complications.


essential hypertension; angiogenesis; vascular endothelial growth factor; angiopoetin-2; inflammation


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