Evaluating the prognostic significance of carotid intima-media thickness and the nature of hypertension in the recognition of cognitive impairment

Authors

  • S.S. Boev State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine
  • N.Ya. Dotsenko State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine
  • L.V. Gerasimenko State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine
  • I.A. Shekhunova State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine
  • A.V. Molodan State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine
  • A.Ya. Malynovskaya State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine

DOI:

https://doi.org/10.22141/2224-1485.3.59.2018.139902

Keywords:

когнітивні порушення, гіпертонічна хвороба, товщина комплексу інтима-медіа, ROC-аналіз

Abstract

Background. At present, the problem of high blood pressure as a risk factor for cognitive impairment is of great inte-rest. The purpose was to evaluate the prognostic significance of carotid intima-media thickness and the nature of hypertension course in the recognition of cognitive impairment. Materials and methods. Seventy six patients with stage II hypertension and 12 apparently healthy persons were examined, their mean age was 51.55 ± 0.86 years and 54.25 ± 2.74 years, respectively. Patients were divided into 2 groups, with absence and presence of cognitive impairment assessed using the Montreal Cognitive Assessment test. In order to evaluate the prognostic significance of indicators, the analysis of performance curves (ROC-analysis) was used to determine the risk of cognitive impairment in patients with essential hypertension. Results. In the group with stage II hypertensive disease and cognitive impairment, the proportion of patients with carotid intima-media thickness higher than normal and the proportion of patients with frequent hypertensive crises was higher than in group without cognitive impairment and amounted to 61.1 and 63.8  %, respectively. The area under the ROC curve for the carotid intima-media thickness, the incidence of hypertensive crises and the coefficient of cognitive impairment when predicting the risk of cognitive impairment in hypertensive patients was 0.60 ± 0.07; 0.68 ± 0.06; 0.80 ± 0.05, respectively. This indicates a bad, average and good quality of the model, respectively. Conclusions. The coefficient of cognitive impairment more than 3.10 is significantly associated with their development in patients with essential hypertension and can serve as a marker for predicting cognitive dysfunction.

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References

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Published

2021-09-27

How to Cite

Boev, S., Dotsenko, N., Gerasimenko, L., Shekhunova, I., Molodan, A., & Malynovskaya, A. (2021). Evaluating the prognostic significance of carotid intima-media thickness and the nature of hypertension in the recognition of cognitive impairment. HYPERTENSION, (3.59), 7–13. https://doi.org/10.22141/2224-1485.3.59.2018.139902

Issue

Section

Clinical Researches

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